ISSN 0371-0874, CN 31-1352/Q



程明星1, 李晨辉1, 孟卫2, 王琛1,*

1中国药科大学生命科学与技术学院,天然药物活性组分与药效国家重点实验室,南京 211198;2中国药科大学理学院,南京 211198



关键词: 缺血性脑卒中; 小胶质细胞; 炎症反应; 吞噬作用


Dual roles and mechanism of microglia in ischemic stroke

CHENG Ming-Xing1, LI Chen-Hui1, MENG Wei2, WANG Chen1,*

1State Key Laboratory of Natural Medicines, School of Life Science and Technologye, China Pharmaceutical University, Nanjing 211198, China ;2School of Science, China Pharmaceutical University, Nanjing 211198, China


Stroke is the second most common cause of death after cancer worldwide and a major cause of acquired disability in adults. Overwhelming majority of strokes are caused by cerebral ischemia and are classified as ischemic stroke. Microglia are the resident immune cells and play dual roles in response to ischemia injury in the central nervous system (CNS). On the one hand, microglia may contribute to tissue function recovery process by promoting inflammation resolution, cellular debris clearance, nerve regeneration and synapse remodeling. On the other hand, excessive activation of microglia aggravates nerve damage after ischemic injury. Here, we briefly describe the mechanism of microglia activation after stroke, and comprehensively review the dual role of microglia in neurodegeneration and regeneration after stroke. In-depth exploration of the cytotoxic and protective mechanisms of microglia will provide new targets and new strategies for stroke treatment.

Key words: ischemic stroke; microglia; inflammation; phagocytosis

收稿日期:2020-12-18  录用日期:2021-02-26

通讯作者:王琛  E-mail:


程明星, 李晨辉, 孟卫, 王琛. 小胶质细胞在缺血性脑卒中中的双重作用及机制[J]. 生理学报 2021; 73 (6): 963-972.

CHENG Ming-Xing, LI Chen-Hui, MENG Wei, WANG Chen. Dual roles and mechanism of microglia in ischemic stroke. Acta Physiol Sin 2021; 73 (6): 963-972 (in Chinese with English abstract).