ISSN 0371-0874, CN 31-1352/Q

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神经-免疫调控在呼吸道疾病中的研究进展

杨中英, 臧娜, 刘恩梅*

重庆医科大学附属儿童医院呼吸科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿童感染免疫重庆市重点实验室,重庆 400014

摘要

神经系统和免疫系统相对独立又相互作用,神经-免疫调控对于呼吸系统抵御外界有害刺激、维持稳态至关重要。神经-免疫之间密切关联、相互作用,参与了呼吸道疾病的发生与发展过程,形成了对炎症等反应监测和调节的环路。本文综述呼吸系统的神经-免疫调控及其在呼吸道疾病中的作用,为深入了解神经-免疫的交联效应、探索其在呼吸道疾病中的作用机制提供理论基础,为呼吸系统疾病的防治提供新思路。


关键词: 神经-免疫; 神经-免疫相互作用; 呼吸系统疾病

Neuro-immune interactions in respiratory diseases

YANG Zhong-Ying, ZANG Na, LIU En-Mei*

Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China

Abstract

The nervous system and the immune system are relatively independent but interactional, and neuro-immune regulation is very important for the respiratory system to resist external harmful stimuli and to maintain homeostasis. Neuro-immune interaction is involved in the occurrence and development of respiratory diseases, and is essential for monitoring and modulating inflammation and tissue repair. This article summaries the neuro-immune regulation of respiratory system and discusses its role in respiratory diseases, aiming to provide a theoretical basis for further understanding the crosstalk between the nervous and immune systems, to explore the underlying mechanism in respiratory diseases, and to provide new thoughts for the prevention and treatment of respiratory diseases.


Key words: neuro-immune; neuro-immune crosstalk; respiratory diseases

收稿日期:  录用日期:

通讯作者:刘恩梅  E-mail: emliu186@126.com

引用本文:

杨中英, 臧娜, 刘恩梅. 神经-免疫调控在呼吸道疾病中的研究进展[J]. 生理学报 2022; 74 (3): 434-442.

YANG Zhong-Ying, ZANG Na, LIU En-Mei. Neuro-immune interactions in respiratory diseases. Acta Physiol Sin 2022; 74 (3): 434-442 (in Chinese with English abstract).