ISSN 0371-0874, CN 31-1352/Q

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运动改善非酒精性脂肪性肝病的内质网应激机制研究进展

蒋昌君, 李军汉*

成都体育学院运动医学与健康学院,成都 610041

摘要

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是代谢综合征的主要疾病之一。随着NAFLD在全球范围内的日益流行,NAFLD的防治面临巨大的挑战。近些年,国内外学者针对NAFLD开展了大量研究,但其发病机制仍不清楚。内质网应激(endoplasmic reticulum stress, ERS)是由未折叠或错误折叠蛋白的积累所引起,作为对ERS的反应,细胞通过启动未折叠蛋白反应(unfolded protein response, UPR)的保护机制来帮助恢复正常的内质网功能。肝细胞脂质异常积聚、炎症反应加剧、肝细胞凋亡增加和胰岛素抵抗(insulin resistance, IR)是NAFLD的主要发病因素和特征,与肝脏ERS密切相关。大量研究表明,运动作为一种低成本治疗手段,可有效预防和改善NAFLD,其机制与运动调节ERS水平相关。本文从ERS的角度,综述运动改善NAFLD的作用机制研究进展。运动改善NAFLD的机制与运动通过调节ERS来调控肝细胞脂质代谢、减轻炎症反应、减少肝细胞凋亡和改善IR有关。


关键词: 非酒精性脂肪性肝病; 运动; 内质网应激; 分子机制

Research progress on mechanism of exercise improving non-alcoholic fatty liver  disease through regulating endoplasmic reticulum stress

JIANG Chang-Jun, LI Jun-Han*

School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the main diseases of metabolic syndrome. With the increasing popularity of NAFLD in the world, the prevention and therapy of NAFLD are facing great challenges. In recent years, scholars at home and abroad have carried out a large number of studies on NAFLD, but its pathogenesis is still unclear. Endoplasmic reticulum stress (ERS) is caused by the accumulation of unfolded or misfolded proteins. In response to ERS, cells help restore normal endoplasmic reticulum function by initiating a protective mechanism known as the unfolded protein response (UPR). Abnormal accumulation of lipids in hepatocytes, aggravated inflammatory response, increased apoptosis of hepatocytes and insulin resistance (IR) are the main pathogenic factors and characteristics of NAFLD, which are closely related to hepatic ERS. A large number of studies have shown that exercise, as a low-cost treatment, can prevent and improve NAFLD effectively, and its mechanism is related to exercise regulating the level of ERS. This paper reviews the research progress on the mechanism of exercise improving NAFLD from the point of view of ERS. The mechanism of exercise improving NAFLD is related to the regulation of hepatocyte lipid metabolism, alleviation of inflammatory reaction, reduction of hepatocyte apoptosis and improvement of IR through regulating ERS.


Key words: non-alcoholic fatty liver disease; exercise; endoplasmic reticulum stress; molecular mechanism

收稿日期:  录用日期:

通讯作者:李军汉  E-mail: junhanli@cdsu.edu.cn

DOI: 10.13294/j.aps.2022.0074

引用本文:

蒋昌君, 李军汉. 运动改善非酒精性脂肪性肝病的内质网应激机制研究进展[J]. 生理学报 2022; 74 (5): 816-826.

JIANG Chang-Jun, LI Jun-Han. Research progress on mechanism of exercise improving non-alcoholic fatty liver  disease through regulating endoplasmic reticulum stress. Acta Physiol Sin 2022; 74 (5): 816-826 (in Chinese with English abstract).