血管钙化是导致慢性肾脏病(chronic kidney disease, CKD)患者高心血管疾病发病率和死亡率的关键因素，造成了极大的医疗卫生及经济负担，探索其发病机制及干预手段十分迫切。CKD血管钙化是受多种细胞主动调控的异位成骨过程。血管平滑肌细胞(vascular smooth muscle cells, VSMCs)在促钙化环境下发生成骨样转分化，分泌基质囊泡形成钙磷结晶沉积位点是CKD血管钙化发生和发展的关键事件。本文就CKD血管钙化研究新机制、新技术及肌肉细胞因子鸢尾素(Irisin)在CKD血管钙化中的作用及机制进行综述。
New mechanisms of chronic kidney disease-associated vascular calcification
WANG Pei-Wen, ZHANG Ai-Hua*
Xuanwu Hospital of Capital Medical University, Beijing 100053, China
Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.
Key words: chronic kidney disease; vascular calcification; pathogenesis; Irisin
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王佩文, 张爱华. 慢性肾脏病相关的血管钙化发病新机制[J]. 生理学报 2022; 74 (6): 913-926.
WANG Pei-Wen, ZHANG Ai-Hua. New mechanisms of chronic kidney disease-associated vascular calcification. Acta Physiol Sin 2022; 74 (6): 913-926 (in Chinese with English abstract).