ISSN 0371-0874, CN 31-1352/Q



常熙雯1,2, 赵安鹏1,2, 姚菀腾1,2, 李文斌1, 王荣1,2,*

1中国人民解放军联勤保障部队第九四〇医院药剂科,兰州 730050;2兰州大学药学院,兰州 730000



关键词: 铁死亡; 高原低氧; 缺血再灌注; 新生儿缺氧缺血性脑损伤; 阻塞性睡眠呼吸暂停; 间歇性低氧

Research progress of ferroptosis in hypoxia-associated brain injury 

CHANG Xi-Wen1,2, ZHAO An-Peng1,2, YAO Wan-Teng1,2, LI Wen-Bin1, WANG Rong1,2,*

1Department of Pharmacy, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China;2School of Pharmacy, Lanzhou University, Lanzhou 730000, China


Cerebral hypoxia often brings irreversible damage to the central nervous system, which seriously endangers human health. It is of great significance to further explore the mechanism of hypoxia-associated brain injury. As a programmed cell death, ferroptosis mainly manifests as cell death caused by excessive accumulation of iron-dependent lipid peroxides. It is associated with abnormal glutathione metabolism, lipid peroxidation and iron metabolism, and is involved in the occurrence and development of various diseases. Studies have found that ferroptosis plays an important role in hypoxia-associated brain injury. This review summarizes the mechanism of ferroptosis, and describes its research progress in cerebral ischemia reperfusion injury, neonatal hypoxic-ischemic brain damage, obstructive sleep apnea-induced brain injury and high-altitude hypoxic brain injury.

Key words: ferroptosis; high-altitude hypoxia; ischemia-reperfusion; hypoxic-ischemic brain damage; obstructive sleep apnea; intermittent hypoxia

收稿日期:  录用日期:

通讯作者:王荣  E-mail:

DOI: 10.13294/j.aps.2023.0018


常熙雯, 赵安鹏, 姚菀腾, 李文斌, 王荣. 铁死亡在缺氧相关脑损伤中的研究进展[J]. 生理学报 2023; 75 (2): 255-268.

CHANG Xi-Wen, ZHAO An-Peng, YAO Wan-Teng, LI Wen-Bin, WANG Rong. Research progress of ferroptosis in hypoxia-associated brain injury . Acta Physiol Sin 2023; 75 (2): 255-268 (in Chinese with English abstract).