ISSN 0371-0874, CN 31-1352/Q

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Prostate organoid technology – the new POT of gold in prostate stem cell and cancer research

MAI Chun-Wai11,2,3, , , SHU Yu1

1State Key Laboratory of Oncogenes and Related Genes, Ren Ji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;2Centre for Stem Cell Research, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor 43000, Malaysia;3School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia

Abstract

Organoids are self-organized cellular clusters in three-dimensional culture, which can be derived from a single stem cell, progenitor or cell clusters of different lineages resembling in vivo tissue architecture of an organ. In the recent years, organoids technology has contributed to the revolutionary changes in stem cell and cancer fields. In this review, we have briefly overviewed the emerging landscape of prostate organoid technology (POT) in prostate research. In addition, we have also summarized the potential application of POT in the understanding of prostate stem cell and cancer biology and the discovery of novel therapeutic strategies for prostate cancer. Lastly, we have critically discussed key challenges that lie in the current state of POT and provided a future perspective on the second-generation of POT, which should better recapitulate cellular behaviors and drug responses of prostate cancer patients.


Key words: organoids; three-dimensional cell culture; tumor model; prostate stem cells or progenitors; prostate cancer

Received: 2020-12-06  Accepted: 2021-03-11

Corresponding author: CHUA Chee Wai  E-mail: cheewaichua@yahoo.com

Citing This Article:

MAI Chun-Wai1, SHU Yu, CHEONG Soon-Keng, CHUA Chee Wai. Prostate organoid technology – the new POT of gold in prostate stem cell and cancer research. Acta Physiol Sin 2021; 73 (2): 181-196