Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention
LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun*
Department of Sports and Cardiovascular Health, Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi’an 710119, China
Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.
Received: 2020-06-18 Accepted: 2020-11-04
Corresponding author: TIAN Zhen-Jun E-mail: firstname.lastname@example.org
Citing This Article：
LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun. Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention. Acta Physiol Sin 2021; 73 (2): 342-352 (in Chinese with English abstract).