ISSN 0371-0874, CN 31-1352/Q

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Factors affecting pulmonary arterial pressure in response to high-altitude hypoxic stress 

ZHOU Zhen, TANG Feng, GE Ri-Li*

Research Center for High Altitude Medicine, Qinghai University; the Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province; Key Laboratory of High Altitude Medicine (Ministry of Education), Xining 810001, China


The alteration of pulmonary artery pressure is an important physiological indicator to reflect the organism’s adaptation to acclimatization or the pathological injury in response to high-altitude hypoxic environment. The effects of hypoxic stress at different altitudes for different time on pulmonary artery pressure are different. There are many factors involved in the changes of pulmonary artery pressure, such as the contraction of pulmonary arterial smooth muscle, hemodynamic changes, abnormal regulation of vascular activity and abnormal changes of cardiopulmonary function. Understanding of the regulatory factors of pulmonary artery pressure in hypoxic environment is crucial in clarifying the relevant mechanisms of hypoxic adaptation, acclimatization, prevention, diagnosis, treatment and prognosis of acute and chronic high-altitude diseases. In recent years, great progress has been made in the study regarding the factors affecting pulmonary artery pressure in response to high-altitude hypoxic stress. In this review, we discuss the regulatory factors and intervention measures of pulmonary arterial hypertension induced by hypoxia from the aspects of hemodynamics of circulatory system, vasoactive state and changes of cardiopulmonary function. 

Key words: high altitude; hypoxia; pulmonary artery pressure; pulmonary arterial hypertension

Received:   Accepted:

Corresponding author: GE Ri-Li  E-mail:

DOI: 10.13294/j.aps.2023.0003

Citing This Article:

ZHOU Zhen, TANG Feng, GE Ri-Li. Factors affecting pulmonary arterial pressure in response to high-altitude hypoxic stress . Acta Physiol Sin 2023; 75 (1): 130-136 (in Chinese with English abstract).